Interleukin-10 inhibits tumor metastasis, downregulates MHC class I, and enhances NK lysis
N Kundu, AM Fulton - Cellular Immunology, 1997 - Elsevier
We have engineered highly aggressive murine mammary tumor cell line 410.4 to express
interleukin-10 (IL-10) and compared the behaviorin vivoof these cells to parental 410.4 and
410.4 transfected with the control plasmid (410.4-neo). Transplantation of parental 410.4
and 410.4-neo tumor cells to syngeneic mice resulted in progressive growth and death from
pulmonary metastases. In contrast, both subcutaneous growth and metastatic disease were
completely inhibited by IL-10 expression. We had shown previously that the antimetastatic …
interleukin-10 (IL-10) and compared the behaviorin vivoof these cells to parental 410.4 and
410.4 transfected with the control plasmid (410.4-neo). Transplantation of parental 410.4
and 410.4-neo tumor cells to syngeneic mice resulted in progressive growth and death from
pulmonary metastases. In contrast, both subcutaneous growth and metastatic disease were
completely inhibited by IL-10 expression. We had shown previously that the antimetastatic …