Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion
MP Colombo, A Mantovani - Cancer research, 2005 - AACR
Cancer research, 2005•AACR
Tumor development and progression are strongly linked to inflammation and the presence
of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be
achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling,
or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of
conventional cancer therapeutic strategies by targeting TAMs.
of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be
achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling,
or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of
conventional cancer therapeutic strategies by targeting TAMs.
Abstract
Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.
AACR