Paraneoplastic cerebellar degeneration: Yo-expressing tumor revealed after a 5-year follow-up with FDG-PET
We report a patient with anti-Yo associated paraneoplastic cerebellar degeneration (PCD)
whose tumor was demonstrated 5 years after developing PCD and had strong expression of
Yo (cdr2) antigen. Review of this case along with clinical series and studies of tumor growth
rates question the effectiveness of the anti-tumor immune response. These studies and
similar cases suggest that the tumor may trigger the anti-Yo immune response at
microscopic stages of development. An overwhelming majority of anti-Yo positive patients …
whose tumor was demonstrated 5 years after developing PCD and had strong expression of
Yo (cdr2) antigen. Review of this case along with clinical series and studies of tumor growth
rates question the effectiveness of the anti-tumor immune response. These studies and
similar cases suggest that the tumor may trigger the anti-Yo immune response at
microscopic stages of development. An overwhelming majority of anti-Yo positive patients …