[HTML][HTML] Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation
Homologous recombination plays a fundamental role in DNA double-strand break repair.
Previously, we detected two mammalian nuclear proteins of 100 and 75 kDa (POMp100 and
POMp75, respectively) that are able to promote homologous DNA pairing, a key step in
homologous recombination. Here we describe the identification of human (h) POMp75 as
the pro-oncoprotein TLS/FUS. hPOMp75/TLS binds both single-and double-stranded DNAs
and mediates annealing of complementary DNA strands. More important, it promotes the …
Previously, we detected two mammalian nuclear proteins of 100 and 75 kDa (POMp100 and
POMp75, respectively) that are able to promote homologous DNA pairing, a key step in
homologous recombination. Here we describe the identification of human (h) POMp75 as
the pro-oncoprotein TLS/FUS. hPOMp75/TLS binds both single-and double-stranded DNAs
and mediates annealing of complementary DNA strands. More important, it promotes the …