Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications
NS Wilson, JA Villadangos - Advances in immunology, 2005 - Elsevier
Dendritic cells (DCs) are central to the maintenance of immunological tolerance and the
initiation and control of immunity. The antigen-presenting properties of DCs enable them to
present a sample of self and foreign proteins, contained within an organism at any given
time, to the T-cell repertoire. DCs achieve this communication with T cells by displaying
antigenic peptides bound to MHC I and MHC II molecules. Here we review the studies
carried out over the past 15 years to characterize these antigen presentation mechanisms …
initiation and control of immunity. The antigen-presenting properties of DCs enable them to
present a sample of self and foreign proteins, contained within an organism at any given
time, to the T-cell repertoire. DCs achieve this communication with T cells by displaying
antigenic peptides bound to MHC I and MHC II molecules. Here we review the studies
carried out over the past 15 years to characterize these antigen presentation mechanisms …