When ligand becomes receptor—tolerance via B7 signaling on DCs
EB Finger, JA Bluestone - Nature immunology, 2002 - nature.com
EB Finger, JA Bluestone
Nature immunology, 2002•nature.comWhen ligand becomes receptor—tolerance via B7 signaling on DCs | Nature Immunology Skip
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CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.
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