[HTML][HTML] Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
J Wang, N Simonavicius, X Wu, G Swaminath… - Journal of biological …, 2006 - ASBMB
Local catabolism of the essential amino acid tryptophan is considered an important
mechanism in regulating immunological and neurological responses. The kynurenine
pathway is the main route for the non-protein metabolism of tryptophan. The intermediates of
the kynurenine pathway are present at micromolar concentrations in blood and are
regulated by inflammatory stimuli. Here we show that GPR35, a previously orphan G protein-
coupled receptor, functions as a receptor for the kynurenine pathway intermediate kynurenic …
mechanism in regulating immunological and neurological responses. The kynurenine
pathway is the main route for the non-protein metabolism of tryptophan. The intermediates of
the kynurenine pathway are present at micromolar concentrations in blood and are
regulated by inflammatory stimuli. Here we show that GPR35, a previously orphan G protein-
coupled receptor, functions as a receptor for the kynurenine pathway intermediate kynurenic …