[HTML][HTML] Expression of indoleamine 2, 3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses
SC Beutelspacher, PH Tan, MO McClure… - American journal of …, 2006 - Elsevier
Indoleamine 2, 3-dioxygenase (IDO) is an important enzyme in the regulation of immune
responses; cells that express IDO can suppress T-cell responses and promote tolerance.
Because of the critical role of endothelial cells in graft rejection, we have investigated the
role of IDO expression by vascular endothelial cells and its consequence on
immunoregulation. We compared the expression of IDO by primary human umbilical vein
endothelial cells (HUVECs), human saphenous vein endothelial cells (HSVECs) and …
responses; cells that express IDO can suppress T-cell responses and promote tolerance.
Because of the critical role of endothelial cells in graft rejection, we have investigated the
role of IDO expression by vascular endothelial cells and its consequence on
immunoregulation. We compared the expression of IDO by primary human umbilical vein
endothelial cells (HUVECs), human saphenous vein endothelial cells (HSVECs) and …