Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and …

AJ Saxby, A Nielsen, CJ Scarlett… - The American journal …, 2005 - journals.lww.com
HER-2 is a transmembrane growth factor receptor recognized in overexpression as an
independent adverse prognostic factor in several cancers. This study measured HER-2
overexpression in pancreatic adenocarcinoma at the genetic, transcriptional, and
translational level. Expression was gauged with regard to stage, grade, and survival.
Pancreatic adenocarcinoma samples (n= 30) were analyzed with immunohistochemical
labeling for HER-2 protein, Quantitative real-time reverse transcriptase polymerase chain …