Dealing with energy demand: the AMP-activated protein kinase
BE Kemp, KI Mitchelhill, D Stapleton, BJ Michell… - Trends in biochemical …, 1999 - cell.com
BE Kemp, KI Mitchelhill, D Stapleton, BJ Michell, ZP Chen, LA Witters
Trends in biochemical sciences, 1999•cell.comThe AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein
kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise,
nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell
metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose
deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism
through to transcriptional control.
kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise,
nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell
metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose
deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism
through to transcriptional control.
Abstract
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.
cell.com