The findings that insulin resistance has important implications in the pathogenesis of the
polycystic ovary syndrome (PCOS) and that insulin-sensitizing drugs are a useful
therapeutic approach are relatively recent. Nevertheless, multiple well-designed clinical
trials have been published in the past decade, and there is now sufficient evidence in the
literature to support clinical recommendations. The management of PCOS includes short-
term objectives, such as treatment of infertility and control of androgen excess, as well as …