Calcium responses in human fibroblasts: a diagnostic molecular profile for Alzheimer's disease
N Hirashima, R Etcheberrigaray, S Bergamaschi… - Neurobiology of …, 1996 - Elsevier
Neurobiology of aging, 1996•Elsevier
We have previously identified alterations of K+ channel function, IP3-mediated calcium
release, and Cp20 (a memory-associated GTP binding protein) in fibroblasts from AD
patients vs. controls. In the present study we introduce a fibroblasts. This scoring system
generates an index that distinguishes AD patients from controls with both high specificity
and sensitivity. We also show that low doses of bradykinin elicit intracellular calcium release
almost exclusively in AD cell lines in an all or none fashion that provide a clear …
release, and Cp20 (a memory-associated GTP binding protein) in fibroblasts from AD
patients vs. controls. In the present study we introduce a fibroblasts. This scoring system
generates an index that distinguishes AD patients from controls with both high specificity
and sensitivity. We also show that low doses of bradykinin elicit intracellular calcium release
almost exclusively in AD cell lines in an all or none fashion that provide a clear …
We have previously identified alterations of K+ channel function, IP3-mediated calcium release, and Cp20 (a memory-associated GTP binding protein) in fibroblasts from AD patients vs. controls. In the present study we introduce a fibroblasts. This scoring system generates an index that distinguishes AD patients from controls with both high specificity and sensitivity. We also show that low doses of bradykinin elicit intracellular calcium release almost exclusively in AD cell lines in an all or none fashion that provide a clear measurement of enhanced IP3-mediated function in AD vs. controls.
Elsevier