[HTML][HTML] Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-β on long term potentiation and cell death in hippocampus: a role …
AM Minogue, AW Schmid, MP Fogarty… - Journal of Biological …, 2003 - ASBMB
Amyloid-β (Aβ) is a major constituent of the neuritic plaque found in the brain of Alzheimer's
disease patients, and a great deal of evidence suggests that the neuronal loss that is
associated with the disease is a consequence of the actions of Aβ. In the past few years, it
has become apparent that activation of c-Jun N-terminal kinase (JNK) mediates some of the
effects of Aβ on cultured cells; in particular, the evidence suggests that Aβ-triggered JNK
activation leads to cell death. In this study, we investigated the effect of …
disease patients, and a great deal of evidence suggests that the neuronal loss that is
associated with the disease is a consequence of the actions of Aβ. In the past few years, it
has become apparent that activation of c-Jun N-terminal kinase (JNK) mediates some of the
effects of Aβ on cultured cells; in particular, the evidence suggests that Aβ-triggered JNK
activation leads to cell death. In this study, we investigated the effect of …