[HTML][HTML] A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells
Z Liu, Y Tang, T Qiu, X Cao, TL Clemens - Journal of Biological Chemistry, 2006 - ASBMB
Genetic evidence from both humans and mice suggests that Wnt/β-catenin and bone
morphogenetic protein (BMP) signaling pathways are essential for bone marrow
mesenchymal stem cells to differentiate into osteoblasts. Here we describe a mechanism
through which BMPs antagonize Wnt signaling and retard bone marrow mesenchymal stem
cell proliferation. Treatment with Wnt3a, but not BMP-2, stimulated Lef1-mediated
transcriptional activity, whereas co-stimulation with both Wnt3a and BMP-2 markedly …
morphogenetic protein (BMP) signaling pathways are essential for bone marrow
mesenchymal stem cells to differentiate into osteoblasts. Here we describe a mechanism
through which BMPs antagonize Wnt signaling and retard bone marrow mesenchymal stem
cell proliferation. Treatment with Wnt3a, but not BMP-2, stimulated Lef1-mediated
transcriptional activity, whereas co-stimulation with both Wnt3a and BMP-2 markedly …