[HTML][HTML] Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK
W Li, T Zhu, KL Guan - Journal of Biological Chemistry, 2004 - ASBMB
The Ras oncoproteins activate the Raf-MEK-ERK kinase pathway, which plays an important
role in cellular transformation. We observed that H-RasV12 exhibited a higher transforming
potential than either K-RasV12 or N-RasV12 in both NIH3T3 fibroblasts and RIE-1 rat
epithelial cell cultures. Surprisingly N-Ras and K-Ras were more potent than H-Ras in
activation of mitogen-activated protein (MAP) kinase activity and ternary complex factor-
dependent transcription. In contrast, H-Ras was more effective in activation of …
role in cellular transformation. We observed that H-RasV12 exhibited a higher transforming
potential than either K-RasV12 or N-RasV12 in both NIH3T3 fibroblasts and RIE-1 rat
epithelial cell cultures. Surprisingly N-Ras and K-Ras were more potent than H-Ras in
activation of mitogen-activated protein (MAP) kinase activity and ternary complex factor-
dependent transcription. In contrast, H-Ras was more effective in activation of …