[HTML][HTML] Increasing complexity of the Ras signaling pathway
AB Vojtek, CJ Der - Journal of Biological Chemistry, 1998 - ASBMB
Ras is a key regulator of cell growth in all eukaryotic cells. Genetic, biochemical, and
molecular studies in Caenorhabditis elegans, Drosophila, and mammalian cells have
positioned Ras centrally in signal transduction pathways that respond to diverse
extracellular stimuli, including peptide growth factors, cytokines, and hormones. The
biological activity of Ras is controlled by a regulated GDP/GTP cycle. Guanine nucleotide
exchange factors (GEFs1; RasGRF1/2 and Sos1/2) promote the formation of the active, GTP …
molecular studies in Caenorhabditis elegans, Drosophila, and mammalian cells have
positioned Ras centrally in signal transduction pathways that respond to diverse
extracellular stimuli, including peptide growth factors, cytokines, and hormones. The
biological activity of Ras is controlled by a regulated GDP/GTP cycle. Guanine nucleotide
exchange factors (GEFs1; RasGRF1/2 and Sos1/2) promote the formation of the active, GTP …