[HTML][HTML] Functional comparison of the K+-Cl− cotransporters KCC1 and KCC4
The K+-Cl− cotransporters (KCCs) are members of the cation-chloride cotransporter gene
family and fall into two phylogenetic subgroups: KCC2 paired with KCC4 and KCC1 paired
with KCC3. We report a functional comparison in Xenopus oocytes of KCC1 and KCC4,
widely expressed representatives of these two subgroups. KCC1 and KCC4 exhibit
differential sensitivity to transport inhibitors, such that KCC4 is much less sensitive to
bumetanide and furosemide. The efficacy of these anion inhibitors is critically dependent on …
family and fall into two phylogenetic subgroups: KCC2 paired with KCC4 and KCC1 paired
with KCC3. We report a functional comparison in Xenopus oocytes of KCC1 and KCC4,
widely expressed representatives of these two subgroups. KCC1 and KCC4 exhibit
differential sensitivity to transport inhibitors, such that KCC4 is much less sensitive to
bumetanide and furosemide. The efficacy of these anion inhibitors is critically dependent on …