Rap1 signalling: adhering to new models
JL Bos, J de Rooij, KA Reedquist - Nature reviews Molecular cell …, 2001 - nature.com
JL Bos, J de Rooij, KA Reedquist
Nature reviews Molecular cell biology, 2001•nature.comRas-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches
that couple extracellular signals to various cellular responses. Rap1, the closest relative of
Ras, has attracted much attention because of the possibility that it regulates Ras-mediated
signalling. Rap1 is activated by extracellular signals through several regulatory proteins,
and it might function in diverse processes, ranging from modulation of growth and
differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.
that couple extracellular signals to various cellular responses. Rap1, the closest relative of
Ras, has attracted much attention because of the possibility that it regulates Ras-mediated
signalling. Rap1 is activated by extracellular signals through several regulatory proteins,
and it might function in diverse processes, ranging from modulation of growth and
differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.
Abstract
Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1, the closest relative of Ras, has attracted much attention because of the possibility that it regulates Ras-mediated signalling. Rap1 is activated by extracellular signals through several regulatory proteins, and it might function in diverse processes, ranging from modulation of growth and differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.
nature.com