Anticoagulant dermatan sulfate proteoglycan (decorin) in the term human placenta
MA Delorme, L Xu, L Berry, L Mitchell, M Andrew - Thrombosis research, 1998 - Elsevier
Normal pregnancy is characterized by increased in vivo thrombin generation. A greater
proportion of endogenously generated thrombin is complexed to heparin cofactor II in
plasma from pregnant women compared to plasma from nonpregnant ones. The increase in
thrombin-heparin cofactor II complexes suggests that the site of the additional thrombin
generation is relatively rich in dermatan sulfate. We postulated that the site of thrombin
generation may be the placenta since endogenous thrombin generation returns rapidly to …
proportion of endogenously generated thrombin is complexed to heparin cofactor II in
plasma from pregnant women compared to plasma from nonpregnant ones. The increase in
thrombin-heparin cofactor II complexes suggests that the site of the additional thrombin
generation is relatively rich in dermatan sulfate. We postulated that the site of thrombin
generation may be the placenta since endogenous thrombin generation returns rapidly to …