Genetically engineered mice are being used increasingly for delineating the molecular
mechanisms of prostate cancer development. Epithelium-stroma interactions play a critical
role in prostate development and tumorigenesis. To better understand gene expression
patterns in the normal sexually mature mouse prostate, epithelium and stroma were laser-
capture microdissected from ventral, dorsolateral, and anterior prostate lobes. Genome-wide
expression was measured by DNA microarrays. Our analysis indicated that the gene …