What do BMPs do in mammals? Clues from the mouse short-ear mutation
DM Kingsley - Trends in Genetics, 1994 - Elsevier
DM Kingsley
Trends in Genetics, 1994•ElsevierBone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that were
originally isolated on the basis of their remarkable ability to induce the formation of ectopic
bones when implanted into adult animals. The first mutations identified in a mammalian BMP
gene suggest that members of this family induce the formation, patterning and repair of
particular morphological features in higher animals.
originally isolated on the basis of their remarkable ability to induce the formation of ectopic
bones when implanted into adult animals. The first mutations identified in a mammalian BMP
gene suggest that members of this family induce the formation, patterning and repair of
particular morphological features in higher animals.
Abstract
Bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that were originally isolated on the basis of their remarkable ability to induce the formation of ectopic bones when implanted into adult animals. The first mutations identified in a mammalian BMP gene suggest that members of this family induce the formation, patterning and repair of particular morphological features in higher animals.
Elsevier