Mycobacterial purified protein derivatives stimulate innate immunity: malawians show enhanced tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-10 …
RE Weir, GF Black, HM Dockrell, S Floyd… - Infection and …, 2004 - Am Soc Microbiol
RE Weir, GF Black, HM Dockrell, S Floyd, PEM Fine, SD Chaguluka, S Stenson, E King…
Infection and immunity, 2004•Am Soc MicrobiolTo investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG
vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor
alpha, interleukin-1β (IL-1β), and IL-10 responses to mycobacterial purified protein
derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same
for all three cytokines. Before vaccination Malawians made higher pro-and anti-inflammatory
responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects …
vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor
alpha, interleukin-1β (IL-1β), and IL-10 responses to mycobacterial purified protein
derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same
for all three cytokines. Before vaccination Malawians made higher pro-and anti-inflammatory
responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects …
Abstract
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1β (IL-1β), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
American Society for Microbiology