[HTML][HTML] ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice
RG Lee, R Shah, JK Sawyer, RL Hamilton… - Journal of lipid …, 2005 - ASBMB
The relative contributions of ACAT2 and LCAT to the cholesteryl ester (CE) content of VLDL
and LDL were measured. ACAT2 deficiency led to a significant decrease in the percentage
of CE (37.2±2.1% vs. 3.9±0.8%) in plasma VLDL, with a concomitant increase in the
percentage of triglyceride (33.0±3.2% vs. 66.7±2.5%). Interestingly, the absence of ACAT2
had no apparent effect on the percentage CE in LDL, whereas LCAT deficiency significantly
decreased the CE percentage (38.6±4.0% vs. 54.6±1.9%) and significantly increased the …
and LDL were measured. ACAT2 deficiency led to a significant decrease in the percentage
of CE (37.2±2.1% vs. 3.9±0.8%) in plasma VLDL, with a concomitant increase in the
percentage of triglyceride (33.0±3.2% vs. 66.7±2.5%). Interestingly, the absence of ACAT2
had no apparent effect on the percentage CE in LDL, whereas LCAT deficiency significantly
decreased the CE percentage (38.6±4.0% vs. 54.6±1.9%) and significantly increased the …
