[HTML][HTML] Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer
cells, as microRNAs are deregulated consequent to chromosomal alterations and other
genomic abnormalities. The identification of such abnormalities has a clear diagnostic and
prognostic significance, and there are ever increasing examples of links between certain
human cancers and modifications at microRNA loci.
cells, as microRNAs are deregulated consequent to chromosomal alterations and other
genomic abnormalities. The identification of such abnormalities has a clear diagnostic and
prognostic significance, and there are ever increasing examples of links between certain
human cancers and modifications at microRNA loci.
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
The Journal of Clinical Investigation