Mycobacterium tuberculosis is the cause of enormous human morbidity and mortality each
year. Although this bacterium can infect and cause disease in many animals, humans are
the natural host. For the purposes of studying the pathogenesis of M. tuberculosis, as well as
the protective and immunopathologic host responses against this pathogen, suitable animal
models must be used. However, modeling the human infection and disease in animals can
be difficult, and interpreting the data from animal models must be done carefully. In this …