Stem/progenitor and intermediate cell types and the origin of human prostate cancer
EJ Tokar, BB Ancrile, GR Cunha, MM Webber - Differentiation, 2005 - Elsevier
Theories of cell lineage in human prostatic epithelium, based on protein expression,
propose that basal and luminal cells: 1) are either independently capable of self-renewal or
2) arise from stem cells expressing a full spectrum of proteins (p63, cytokeratins CK5/14,
CK8/18, and glutathione-S-transferase-pi [GST-pi]) similar to cells of the embryonic
urogenital sinus (UGS). Such embryonic-like stem cells are thought to give rise to mature
basal cells and secretory luminal cells. By single cell cloning of an immortalized, normal …
propose that basal and luminal cells: 1) are either independently capable of self-renewal or
2) arise from stem cells expressing a full spectrum of proteins (p63, cytokeratins CK5/14,
CK8/18, and glutathione-S-transferase-pi [GST-pi]) similar to cells of the embryonic
urogenital sinus (UGS). Such embryonic-like stem cells are thought to give rise to mature
basal cells and secretory luminal cells. By single cell cloning of an immortalized, normal …
