[HTML][HTML] MicroRNAs in cell proliferation, cell death, and tumorigenesis
HW Hwang, JT Mendell - British journal of cancer, 2006 - nature.com
British journal of cancer, 2006•nature.com
MicroRNAs (miRNAs) are a recently discovered class of∼ 18–24 nucleotide RNA molecules
that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to
regulate basic cellular functions including proliferation, differentiation, and death. It is now
apparent that abnormal miRNA expression is a common feature of human malignancies. In
this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes
and tumour suppressors.
that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to
regulate basic cellular functions including proliferation, differentiation, and death. It is now
apparent that abnormal miRNA expression is a common feature of human malignancies. In
this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes
and tumour suppressors.
Abstract
MicroRNAs (miRNAs) are a recently discovered class of∼ 18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
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