MicroRNAs and cancer
MT McManus - Seminars in cancer biology, 2003 - Elsevier
Seminars in cancer biology, 2003•Elsevier
The general basis of cancer is the loss of cell identity and inappropriate proliferation of cells.
Classically, a universal paradigm in oncogenesis is the accumulation of mutations in the
open reading frames of protein-encoding oncogenes and tumor suppressors. The
identification of new classes of noncoding RNAs (ncRNA) important for development and
cell homeostasis will likely change this current paradigm. Recent data suggests that a
special class of ncRNAs called microRNAs might be involved in human disease. This review …
Classically, a universal paradigm in oncogenesis is the accumulation of mutations in the
open reading frames of protein-encoding oncogenes and tumor suppressors. The
identification of new classes of noncoding RNAs (ncRNA) important for development and
cell homeostasis will likely change this current paradigm. Recent data suggests that a
special class of ncRNAs called microRNAs might be involved in human disease. This review …
The general basis of cancer is the loss of cell identity and inappropriate proliferation of cells. Classically, a universal paradigm in oncogenesis is the accumulation of mutations in the open reading frames of protein-encoding oncogenes and tumor suppressors. The identification of new classes of noncoding RNAs (ncRNA) important for development and cell homeostasis will likely change this current paradigm. Recent data suggests that a special class of ncRNAs called microRNAs might be involved in human disease. This review proposes a role for microRNAs in oncogenesis.
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