[HTML][HTML] High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by …
PG Yancey, M de la Llera-Moya, S Swarnakar… - Journal of Biological …, 2000 - ASBMB
The role of high density lipoprotein (HDL) phospholipid in scavenger receptor BI (SR-BI)-
mediated free cholesterol flux was examined by manipulating HDL 3 phosphatidylcholine
and sphingomyelin content. Both phosphatidylcholine and sphingomyelin enrichment of
HDL enhanced the net efflux of cholesterol from SR-BI-expressing COS-7 cells but by two
different mechanisms. Phosphatidylcholine enrichment of HDL increased efflux, whereas
sphingomyelin enrichment decreased influx of HDL cholesterol. Although similar trends …
mediated free cholesterol flux was examined by manipulating HDL 3 phosphatidylcholine
and sphingomyelin content. Both phosphatidylcholine and sphingomyelin enrichment of
HDL enhanced the net efflux of cholesterol from SR-BI-expressing COS-7 cells but by two
different mechanisms. Phosphatidylcholine enrichment of HDL increased efflux, whereas
sphingomyelin enrichment decreased influx of HDL cholesterol. Although similar trends …