[HTML][HTML] bcr-abl RNA in patients with chronic myelogenous leukemia

E Shtivelman, RP Gale, O Dreazen, A Berrebi, R Zaizov… - Blood, 1987 - Elsevier
E Shtivelman, RP Gale, O Dreazen, A Berrebi, R Zaizov, I Kubonishi, I Miyoshi, E Canaani
Blood, 1987Elsevier
The major consequence of the formation of the Philadelphia (Ph 1) chromosome
characteristic of leukemia cells of patients with chronic myelogenous leukemia (CML) is
fusion of c-abl and bcr genes. Using a sensitive RNase protection technique, we analyzed
mRNA from a large number of CML patients. In most, we identified one or both species of bcr-
abl chimeric transcripts. These two mRNAs vary in the specific bcr exon joined to abl exon II
and are translated into slightly different proteins. The amounts of the fused mRNA within …
The major consequence of the formation of the Philadelphia (Ph1) chromosome characteristic of leukemia cells of patients with chronic myelogenous leukemia (CML) is fusion of c-abl and bcr genes. Using a sensitive RNase protection technique, we analyzed mRNA from a large number of CML patients. In most, we identified one or both species of bcr-abl chimeric transcripts. These two mRNAs vary in the specific bcr exon joined to abl exon II and are translated into slightly different proteins. The amounts of the fused mRNA within leukemia cells vary considerably between individuals and do not correlate with the phase of the disease. © 1987 by Grune & Stratton, Inc.
Elsevier