Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
T Nishida, S Hirota, M Taniguchi, K Hashimoto… - Nature …, 1998 - nature.com
T Nishida, S Hirota, M Taniguchi, K Hashimoto, K Isozaki, H Nakamura, Y Kanakura…
Nature genetics, 1998•nature.comFig. 1 A family with multiple GISTs and mutation of the KIT gene. a, Family pedigree; filled
symbols indicate family members with either intestinal obstruction or the KIT mutation or
both. Squares, males; circles, females; symbols with a dash, dead cases. b, Section of a
benign GIST from case 5 stained with haematoxylin and eosin (H&E). c, Serial section of (b),
the KIT protein expression demonstrated by immunohistochemistry1. d, Section of a
malignant GIST from case 9 stained with H&E. e, Serial section of (d), KIT protein …
symbols indicate family members with either intestinal obstruction or the KIT mutation or
both. Squares, males; circles, females; symbols with a dash, dead cases. b, Section of a
benign GIST from case 5 stained with haematoxylin and eosin (H&E). c, Serial section of (b),
the KIT protein expression demonstrated by immunohistochemistry1. d, Section of a
malignant GIST from case 9 stained with H&E. e, Serial section of (d), KIT protein …
Fig. 1 A family with multiple GISTs and mutation of the KIT gene. a, Family pedigree; filled symbols indicate family members with either intestinal obstruction or the KIT mutation or both. Squares, males; circles, females; symbols with a dash, dead cases. b, Section of a benign GIST from case 5 stained with haematoxylin and eosin (H&E). c, Serial section of (b), the KIT protein expression demonstrated by immunohistochemistry1. d, Section of a malignant GIST from case 9 stained with H&E. e, Serial section of (d), KIT protein expression. Scale bars in (b–e), 25 µm. f, SSCP analysis of KIT exon 11. DNA was extracted from paraffin-embedded specimens (T) or whole blood (L). Arrows indicate mutant bands.
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