Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

E Shtivelman, B Lifshitz, RP Gale, E Canaani - Nature, 1985 - nature.com
E Shtivelman, B Lifshitz, RP Gale, E Canaani
Nature, 1985nature.com
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation
between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and
the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of
chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous
leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be
produced is probably involved in the malignant process.
Abstract
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.
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