[HTML][HTML] Targeting survival: integration site selection by retroviruses and LTR-retrotransposons
FD Bushman - Cell, 2003 - cell.com
Cell, 2003•cell.com
Replication of retroviruses and retrotransposons depends on selecting a favorable
chromosomal site for integration of their genomic DNA. Different retroelements meet this
challenge by targeting distinctive chromosomal regions. Despite these differences, recent
data hints at a common targeting mechanism—tethering of integration complexes to proteins
bound at favorable sites.
chromosomal site for integration of their genomic DNA. Different retroelements meet this
challenge by targeting distinctive chromosomal regions. Despite these differences, recent
data hints at a common targeting mechanism—tethering of integration complexes to proteins
bound at favorable sites.
Abstract
Replication of retroviruses and retrotransposons depends on selecting a favorable chromosomal site for integration of their genomic DNA. Different retroelements meet this challenge by targeting distinctive chromosomal regions. Despite these differences, recent data hints at a common targeting mechanism—tethering of integration complexes to proteins bound at favorable sites.
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