Endocannabinoids and ghrelin are potent appetite stimulators and are known to interact at a
hypothalamic level. However, both also have important peripheral actions, including
beneficial effects on the ischemic heart and increasing adipose tissue deposition, while
ghrelin has direct effects on carbohydrate metabolism. The AMP-activated protein kinase
(AMPK) is a heterotrimeric enzyme that functions as a fuel sensor to regulate energy
balance at both cellular and whole body levels, and it may mediate the action of anti-diabetic …