Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t (5; 12) chromosomal translocation
TR Golub, GF Barker, M Lovett, DG Gilliland - Cell, 1994 - cell.com
TR Golub, GF Barker, M Lovett, DG Gilliland
Cell, 1994•cell.comChronic myelomonocytic leukemia (CYML) is a myelodysplastic syndrome characterized by
abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia
(AML). CMML thus offers an opportunity to study early genetic events in the transition to
AML. A recently recognized subgroup of CYML has at (5; 12)(q33; pl3) balanced
tram&cation. We report that the consequence of the t&12) translocation is expression of a
fusion transcript in which the tyrosine kinase domain of the platelet-derived growth factor …
abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia
(AML). CMML thus offers an opportunity to study early genetic events in the transition to
AML. A recently recognized subgroup of CYML has at (5; 12)(q33; pl3) balanced
tram&cation. We report that the consequence of the t&12) translocation is expression of a
fusion transcript in which the tyrosine kinase domain of the platelet-derived growth factor …
Summary
Chronic myelomonocytic leukemia (CYML) is a myelodysplastic syndrome characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). CMML thus offers an opportunity to study early genetic events in the transition to AML. A recently recognized subgroup of CYML has at (5; 12)(q33; pl3) balanced tram&cation. We report that the consequence of the t&12) translocation is expression of a fusion transcript in which the tyrosine kinase domain of the platelet-derived growth factor receptor 5 (PDGFRB) on chromosome 5 is coupled to a novel e&-like gene, fel, on chromosome 12. The tel-PDGFRfl fusion demonstrates the oncogenic potential of PDGFRf3 and may provide a paradigm for early events in the pathogenesis of AML.
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