[HTML][HTML] The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated …
Shp-2 is a widely expressed cytoplasmic tyrosine phosphatase with two SH2 domains. A
targeted mutant allele of the Shp-2 gene with a deletion of 65 amino acids in the NH 2-
terminal SH2 domain was created that leads to embryonic lethality at mid-gestation in
homozygous mutant mice. To define the Shp-2 function in cell signaling, we have
established mutant fibroblast cell lines, and have examined the effect of the Shp-2 mutation
on extracellular signal-regulated kinase (ERK) and c-Jun NH 2-terminal kinase (JNK) …
targeted mutant allele of the Shp-2 gene with a deletion of 65 amino acids in the NH 2-
terminal SH2 domain was created that leads to embryonic lethality at mid-gestation in
homozygous mutant mice. To define the Shp-2 function in cell signaling, we have
established mutant fibroblast cell lines, and have examined the effect of the Shp-2 mutation
on extracellular signal-regulated kinase (ERK) and c-Jun NH 2-terminal kinase (JNK) …