[HTML][HTML] TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3β
F Yi, PL Brubaker, T Jin - Journal of Biological Chemistry, 2005 - ASBMB
The proglucagon gene (glu) encodes glucagon, expressed in pancreatic islets, and the
insulinotropic hormone GLP-1, expressed in the intestines. These two hormones exert
critical and opposite effects on blood glucose homeostasis. An intriguing question that
remains to be answered is whether and how glu gene expression is regulated in a cell type-
specific manner. We reported previously that the glu gene promoter in gut endocrine cell
lines was stimulated by β-catenin, the major effector of the Wnt signaling pathway, whereas …
insulinotropic hormone GLP-1, expressed in the intestines. These two hormones exert
critical and opposite effects on blood glucose homeostasis. An intriguing question that
remains to be answered is whether and how glu gene expression is regulated in a cell type-
specific manner. We reported previously that the glu gene promoter in gut endocrine cell
lines was stimulated by β-catenin, the major effector of the Wnt signaling pathway, whereas …