[HTML][HTML] Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide
D Liu, C Li, Y Chen, C Burnett, XY Liu, S Downs… - Journal of Biological …, 2004 - ASBMB
Stimulation of macrophages with lipopolysaccharide (LPS) leads to the production of
cytokines that elicit massive liver apoptosis. We investigated the in vivo role of stress-
responsive transcription factors (SRTFs) in this process focusing on the precipitating events
that are sensitive to a cell-permeant peptide inhibitor of SRTF nuclear import (cSN50). In the
absence of cSN50, mice challenged with LPS displayed very early bursts of inflammatory
cytokines/chemokines, tumor necrosis factor α (1 h), interleukin 6 (2 h), interleukin 1 β (2 h) …
cytokines that elicit massive liver apoptosis. We investigated the in vivo role of stress-
responsive transcription factors (SRTFs) in this process focusing on the precipitating events
that are sensitive to a cell-permeant peptide inhibitor of SRTF nuclear import (cSN50). In the
absence of cSN50, mice challenged with LPS displayed very early bursts of inflammatory
cytokines/chemokines, tumor necrosis factor α (1 h), interleukin 6 (2 h), interleukin 1 β (2 h) …