[HTML][HTML] Tumor necrosis factor-α converting enzyme/ADAM 17 mediates MUC1 shedding
A Thathiah, CP Blobel, DD Carson - Journal of Biological Chemistry, 2003 - ASBMB
MUC1 clearance from the uterine epithelial cell surface is a prerequisite for the creation of
an environment conducive to embryo implantation. In some species, reduced mRNA levels
along with metabolic turnover account for loss of MUC1 during the receptive phase
throughout the uterine epithelium. In other species, MUC1 is rapidly lost solely at the site of
blastocyst attachment, suggesting the action of a protease. Correlative studies also indicate
the presence of soluble forms of MUC1 in cell culture supernatants in vitro and in bodily …
an environment conducive to embryo implantation. In some species, reduced mRNA levels
along with metabolic turnover account for loss of MUC1 during the receptive phase
throughout the uterine epithelium. In other species, MUC1 is rapidly lost solely at the site of
blastocyst attachment, suggesting the action of a protease. Correlative studies also indicate
the presence of soluble forms of MUC1 in cell culture supernatants in vitro and in bodily …