Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid
JD Morrow, WG Parsons III, LJ Roberts II - Prostaglandins, 1989 - Elsevier
Nicotinic acid (niacin) is a B which is also a potent hypolipidemic agent. However, intense
flusing occurs following ingestion of harmacology doses of niacin which greatly limits its
usefulness in treating hyperlipidemias. Previous studies have demonstrated that niacin-
induced flusing can be substantially attenuated by pre-treatment with cyclooxygenase
inhibitors, suggesting that the vasodilation is mediated by a prostaglandin. However, the
prostaglandin that presumably mediates the flush has not bee conclusively determined. In …
flusing occurs following ingestion of harmacology doses of niacin which greatly limits its
usefulness in treating hyperlipidemias. Previous studies have demonstrated that niacin-
induced flusing can be substantially attenuated by pre-treatment with cyclooxygenase
inhibitors, suggesting that the vasodilation is mediated by a prostaglandin. However, the
prostaglandin that presumably mediates the flush has not bee conclusively determined. In …