Prostaglandins contribute to the vasodilation induced by nicotinic acid
B Eklund, L Kaijser, J Nowak, Å Wennmalm - Prostaglandins, 1979 - Elsevier
The significance of endogenously formed prostaglandins in the vasodilation induced by
nicotinic acid (NIC) was investigated. The forearm venous plasma level of
radioimmunoassayed PGE (R-PGE) and the forearm blood flow (FBF) were measured in 13
healthy male volunteers at rest and during infusion of NIC. Each subject was subsequently
re-studied after pretreatment with the PG synthesis inhibitor, naproxen. In the absence of
naproxen, NIC infusion resulted in an almost four-fold rise in the release of R-PGE and a …
nicotinic acid (NIC) was investigated. The forearm venous plasma level of
radioimmunoassayed PGE (R-PGE) and the forearm blood flow (FBF) were measured in 13
healthy male volunteers at rest and during infusion of NIC. Each subject was subsequently
re-studied after pretreatment with the PG synthesis inhibitor, naproxen. In the absence of
naproxen, NIC infusion resulted in an almost four-fold rise in the release of R-PGE and a …