Local versus indirect action of glucose on the lateral hypothalamic neurons sensitive to glycemic level
JC Orsini, T Himmi, AK Wiser, J Perrin - Brain research bulletin, 1990 - Elsevier
The neuronal activity in the lateral hypothalamus may be affected by moderate changes in
blood glucose. The present study aimed to specify the direct or indirect origin of this
sensitivity to glycemia, by recording the unit responses in this area to both local glucose
application (by means of microelectrophoresis) and hyperglycemia (induced by an IV
glucose injection). The activity of approximately 25% of the recorded LHA neurons was
modified by topically ejected glucose. However, a large majority of these neurons sensitive …
blood glucose. The present study aimed to specify the direct or indirect origin of this
sensitivity to glycemia, by recording the unit responses in this area to both local glucose
application (by means of microelectrophoresis) and hyperglycemia (induced by an IV
glucose injection). The activity of approximately 25% of the recorded LHA neurons was
modified by topically ejected glucose. However, a large majority of these neurons sensitive …