[HTML][HTML] Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-α-converting enzyme
MH Lee, M Rapti, G Murphy - Journal of Biological Chemistry, 2004 - ASBMB
Tumor necrosis factor-α (TNF-α)-converting enzyme (TACE, ADAM-17) is a zinc-dependent
ADAM (adisintegrin and metalloproteinase) metalloproteinase (MP) of the metzincin
superfamily. The enzyme regulates the shedding of a variety of cell surface-anchored
molecules such as cytokines, growth factors, and receptors. The activities of the MPs are
modulated by the endogenous inhibitors, the tissue inhibitor of metalloproteinases (TIMPs).
Among the four mammalian TIMPs (TIMP-1 to-4), TACE is selectively inhibited by TIMP-3 …
ADAM (adisintegrin and metalloproteinase) metalloproteinase (MP) of the metzincin
superfamily. The enzyme regulates the shedding of a variety of cell surface-anchored
molecules such as cytokines, growth factors, and receptors. The activities of the MPs are
modulated by the endogenous inhibitors, the tissue inhibitor of metalloproteinases (TIMPs).
Among the four mammalian TIMPs (TIMP-1 to-4), TACE is selectively inhibited by TIMP-3 …