The functions of thrombospondin-1 and-2

J Lawler - Current opinion in cell biology, 2000 - Elsevier
Current opinion in cell biology, 2000Elsevier
Considerable progress has been made towards understanding the function of
thrombospondin-1 and-2. The description of the phenotype of mice with thrombospondin-1
and-2 knocked-out supports in vitro biochemical and cell-biological data and has opened
new avenues of research. Recently, our understanding of the roles of thrombospondins in
the activation of TGFβ, inhibition of angiogenesis and the initiation of signal transduction has
advanced.
Considerable progress has been made towards understanding the function of thrombospondin-1 and-2. The description of the phenotype of mice with thrombospondin-1 and-2 knocked-out supports in vitro biochemical and cell-biological data and has opened new avenues of research. Recently, our understanding of the roles of thrombospondins in the activation of TGFβ, inhibition of angiogenesis and the initiation of signal transduction has advanced.
Elsevier