[HTML][HTML] The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin
S Goicoechea, MA Pallero, P Eggleton… - Journal of Biological …, 2002 - ASBMB
Thrombospondin (TSP) induces reorganization of the actin cytoskeleton and restructuring of
focal adhesions through binding of amino acids (aa) 17–35 (hep I peptide) of
thrombospondin to a cell surface form of calreticulin (CRT). In this report we provide further
evidence for the involvement of calreticulin in thrombospondin signaling and characterize
thrombospondin-calreticulin interactions. Wild type but notcrt−/− cells respond to hep I/TSP.
Responsiveness can be restored by incubation of cells with exogenous calreticulin or by …
focal adhesions through binding of amino acids (aa) 17–35 (hep I peptide) of
thrombospondin to a cell surface form of calreticulin (CRT). In this report we provide further
evidence for the involvement of calreticulin in thrombospondin signaling and characterize
thrombospondin-calreticulin interactions. Wild type but notcrt−/− cells respond to hep I/TSP.
Responsiveness can be restored by incubation of cells with exogenous calreticulin or by …