The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZBW mice
H Dang, RJ Harbeck - Clinical immunology and immunopathology, 1984 - Elsevier
Employing a hydroxyapatite double-stranded (ds) DNA column for affinity chromatography,
anti-ds-DNA antibodies were isolated from the sera of aging NZB W mice. These antibodies
were radiolabeled and injected intravenously into NZB W mice at various ages. Significant
deposition of radiolabeled antibodies were shown to occur in NZB W mice 4 months of age
and older. While the injected antibodies displayed heterogeneity in their isoelectric points
(pI's), those antibodies which bound to the kidney were restricted to a more alkaline pI …
anti-ds-DNA antibodies were isolated from the sera of aging NZB W mice. These antibodies
were radiolabeled and injected intravenously into NZB W mice at various ages. Significant
deposition of radiolabeled antibodies were shown to occur in NZB W mice 4 months of age
and older. While the injected antibodies displayed heterogeneity in their isoelectric points
(pI's), those antibodies which bound to the kidney were restricted to a more alkaline pI …