[HTML][HTML] Molecular identification of high and low affinity receptors for nicotinic acid
A Wise, SM Foord, NJ Fraser, AA Barnes… - Journal of Biological …, 2003 - ASBMB
Nicotinic acid has been used clinically for over 40 years in the treatment of dyslipidemia
producing a desirable normalization of a range of cardiovascular risk factors, including a
marked elevation of high density lipoprotein and a reduction in mortality. The precise
mechanism of action of nicotinic acid is unknown, although it is believed that activation of a
G iG protein-coupled receptor may contribute. Utilizing available information on the tissue
distribution of nicotinic acid receptors, we identified candidate orphan receptors. The …
producing a desirable normalization of a range of cardiovascular risk factors, including a
marked elevation of high density lipoprotein and a reduction in mortality. The precise
mechanism of action of nicotinic acid is unknown, although it is believed that activation of a
G iG protein-coupled receptor may contribute. Utilizing available information on the tissue
distribution of nicotinic acid receptors, we identified candidate orphan receptors. The …