[HTML][HTML] Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V

T Rabie, A Strehl, A Ludwig, B Nieswandt - Journal of Biological Chemistry, 2005 - ASBMB
Glycoprotein V (GPV) is a subunit of the GPIb-IX-V receptor for von Willebrand factor and
thrombin and has been shown to modulate platelet responses to the two strongest
physiological agonists, thrombin and collagen. Thrombin directly cleaves GPV from the
platelet surface, yielding a 69-kDa fragment GPV f1 of unknown function. We show here that
a∼ 82-kDa fragment of GPV is shed from the platelet surface upon cellular activation with
phorbol 12-myristate 13-acetate or the collagen-related peptide. This shedding was …