Mechanisms and functions of Eph and ephrin signalling

K Kullander, R Klein - Nature reviews Molecular cell biology, 2002 - nature.com
K Kullander, R Klein
Nature reviews Molecular cell biology, 2002nature.com
Eph receptors constitute the largest family of tyrosine kinase receptors and, together with
their plasma-membrane-bound ephrin ligands, have many important functions during
development and adulthood. In contrast with most receptor tyrosine kinases, unidirectional
signalling can originate from the ephrin ligands as well as from the Eph receptors.
Furthermore, the concept of bidirectional signalling has emerged as an important
mechanism by which Ephs and ephrins control the output signal in processes of cell–cell …
Abstract
Eph receptors constitute the largest family of tyrosine kinase receptors and, together with their plasma-membrane-bound ephrin ligands, have many important functions during development and adulthood. In contrast with most receptor tyrosine kinases, unidirectional signalling can originate from the ephrin ligands as well as from the Eph receptors. Furthermore, the concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell–cell communication.
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