[HTML][HTML] Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors: convergence of Gi-and Gq-mediated pathways on calcium …
GJ Della Rocca, T van Biesen, Y Daaka… - Journal of Biological …, 1997 - ASBMB
Many receptors that couple to heterotrimeric guanine-nucleotide binding proteins (G
proteins) have been shown to mediate rapid activation of the mitogen-activated protein
kinases Erk1 and Erk2. In different cell types, the signaling pathways employed appear to be
a function of the available repertoire of receptors, G proteins, and effectors. In HEK-293 cells,
stimulation of either α1B-or α2A-adrenergic receptors (ARs) leads to rapid 5–10-fold
increases in Erk1/2 phosphorylation. Phosphorylation of Erk1/2 in response to stimulation of …
proteins) have been shown to mediate rapid activation of the mitogen-activated protein
kinases Erk1 and Erk2. In different cell types, the signaling pathways employed appear to be
a function of the available repertoire of receptors, G proteins, and effectors. In HEK-293 cells,
stimulation of either α1B-or α2A-adrenergic receptors (ARs) leads to rapid 5–10-fold
increases in Erk1/2 phosphorylation. Phosphorylation of Erk1/2 in response to stimulation of …